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rr88. AMPK mediates ROS-induced longevity. (A – E) Paraquat (0.25 mM) treatment increased the lifespan of wild-type animals. This lifespan extension was suppressed by mutations in genes encoding AMPK pathway components, including aak-2 (ok524) (A and B), aak-2 (rr48) (C), aakb-2 (rr88) (D), and par-4 (tm2986) (E). (F) Percent changes in the lifespan of various C. elegans mutants upon 0.25 mM ...

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